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Risperidone Long-acting Injection Suspension

What is this medicine?

RISPERIDONE (ris PER i done) is used to treat schizophrenia and bipolar disorder. Bipolar disorder is also known as manic-depression.

How should I use this medicine?

This medicine is for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast enlargement in both males and females

  • breathing problems

  • confusion

  • fast, irregular heartbeat

  • fever or chills, sore throat

  • inability to keep still

  • males: prolonged or painful erection

  • missed menstrual periods

  • pain, redness or irritation at site where injected

  • problems with balance, talking, walking

  • redness, blistering, peeling, or loosening of the skin, including inside the mouth

  • seizures

  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • signs and symptoms of neuroleptic malignant syndrome like confusion; fast or irregular heartbeat; high fever; increased sweating; stiff muscles

  • sudden numbness or weakness of the face, arm, or leg

  • suicidal thoughts or other mood changes

  • trouble swallowing

  • uncontrollable movements of the arms, face, head, mouth, neck, or upper body

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance

  • constipation

  • drowsiness

  • dry mouth

  • upset stomach

  • weight gain

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cisapride

  • dextromethorphan; quinidine

  • dronedarone

  • metoclopramide

  • pimozide

  • quinidine

  • thioridazine

This medicine may also interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough, and cold

  • certain medicines for anxiety or sleep

  • certain medicines for depression like amitriptyline, fluoxetine, paroxetine, sertraline

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • levodopa or other medicines for Parkinson's disease

  • medicines for blood pressure

  • medicines for seizures

  • medicines that relax muscles for surgery

  • narcotic medicines for pain

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • phenothiazines like chlorpromazine, prochlorperazine

  • rifampin

What if I miss a dose?

Keep appointments for follow-up doses as directed. It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • dementia

  • diabetes

  • difficulty swallowing

  • have trouble controlling your muscles

  • heart disease

  • high cholesterol

  • high levels of prolactin

  • history of breast cancer

  • history of irregular heartbeat

  • history of stroke

  • kidney disease

  • liver disease

  • low blood counts, like low white cell, platelet, or red cell counts

  • low blood pressure

  • Parkinson's disease

  • seizures

  • an unusual or allergic reaction to risperidone, paliperidone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. Tell your health care professional if your symptoms do not start to get better or if they get worse.

You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This drug can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your health care provider right away.

This medicine may increase blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier
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