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Prochlorperazine injection

What is this medicine?

PROCHLORPERAZINE (proe klor PER a zeen) helps to control severe nausea and vomiting. This medicine is also used to treat schizophrenia. It can also help patients who experience anxiety that is not due to psychological illness.

How should I use this medicine?

This medicine is for injection into a muscle, or injection or infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years of age for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • abnormal production of milk

  • breast enlargement in both males and females

  • changes in vision

  • chest pain

  • confusion

  • fast, irregular heartbeat

  • fever, chills, sore throat

  • seizures

  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • trouble passing urine or change in the amount of urine

  • trouble swallowing

  • uncontrollable movements of the arms, face, head, mouth, neck, or upper body

  • unusual bruising or bleeding

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • drowsiness

  • dry mouth

  • pain, redness, or irritation at site where injected

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cisapride

  • dofetilide

  • dronedarone

  • metoclopramide

  • pimozide

  • saquinavir

  • thioridazine

This medicine may also interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough, and cold

  • atropine

  • certain medicines for anxiety or sleep

  • certain medicines for bladder problems like oxybutynin, tolterodine

  • certain medicines for depression like amitriptyline, fluoxetine, sertraline

  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl

  • certain medicines for stomach problems like dicyclomine, hyoscyamine

  • certain medicines for travel sickness like scopolamine

  • epinephrine

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • ipratropium

  • lithium

  • medicines for high blood pressure

  • medicines for seizures like phenobarbital, primidone, phenytoin

  • medicines that relax muscles for surgery

  • narcotic medicines for pain

  • propranolol

  • warfarin

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • blockage in your bowel

  • brain tumor

  • dementia

  • diabetes

  • difficulty swallowing

  • glaucoma

  • have trouble controlling your muscles

  • head injury

  • heart disease

  • history of irregular heartbeat

  • if you often drink alcohol

  • liver disease

  • low blood counts, like low white cell, platelet, or red cell counts

  • low blood pressure

  • lung or breathing disease, like asthma

  • Parkinson's disease

  • prostate disease

  • seizures

  • trouble passing urine

  • an unusual or allergic reaction to prochlorperazine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This drug can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your health care provider right away.

This medicine may increase blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier
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